Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Studies of various aspects of epilepsy using anatomy and in vivo and in vitro physiology.
Use the olfactory system to examine general problems in the brain maturation, including the role of afferent activity on tissue development and the interplay between evolution and development.
Regulation and Function Serotonergic Neurons During Development
Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
My research is focused on understanding the mechanisms involved in the initiation and progression of the neurodegenerative disease Multiple Sclerosis.
Molecular embryology--gene regulation in cells committed to specific developmental lineages
Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer
Cell Adhesion and Morphogenesis; Cancer mechanisms; Cadherins and catenins; Hippo signaling pathway
Neural control of blood pressure and respiration
Molecular genetics; development and function of neurotransmitter-synthesizing neurons in Drosophila
Synapse Formation and Cell Migration in Normal and Pathobiology-Adhesion, Signaling, Imaging and Proteomics
Pathophysiology of Status Epilepticus; Plasticity of GABAergic Synaptic Transmission
Cellular and molecular mechanisms of morphogenesis
Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegenration
Neuronal Vulnerability: A Study of Cellular Mechanism
Chemical biology of sphingosine 1-phosphate
Molecular Mechanisms of Myotonic Muscular Dystrophy
Mechanisms of Brain Astroglial Activation in Neural Injury
The Cause and Consequence of Somatic Mosaicism in Neurons
Behavioral and Physiological Analysis of Vertebrate Circadian Rhythms
Structure, Function, and Regulation of Cytoplasmic Dynein: Its Role in Intracellular Microtubule-based Transport, Membrane Bounded Organelle Trafficking, Axonal Transport and Mitosis
Apoptotic cell clearance mechanisms in health and disease
Molecular and Cellular Mechanisms of Vertebrate Morphogenesis. Cell Determination and Patterning of the Zebrafish Embryo. Application to Regenerative Medicine and Stem Cell Biology.
Pharmacology and function of T-type (low-voltage-activated, LVA) calcium channels in sensory transmission.
Role of adhesion receptors in regulating axon outgrowth in health and disease, axonal trafficking of adhesion receptors, role of endocytosis and endosomal trafficking in axon outgrowth.
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Development and regulation of retinal ganglion cells (RGCs) and blood vessels as they relate to retinal diseases.
Neural Circuits in Healthy and Diseased Brains