Bloom, George S.

George Bloom

George S. Bloom

Primary Appointment

Professor, Biology

Education

  • BA, Biology, History, University of Pennsylvania
  • PhD, Biology, University of Pennsylvania
  • Postdoc, Cell Biology, University of North Carolina
  • Postdoc, Cell Biology, Worcester Foundation for Exp. Biol

Contact Information

Department of Biology
PO Box 400328
Charlottesville, VA 22904-4328
Telephone: 434-243-3543
Fax: 434-243-3578
Email: gsb4g@virginia.edu
Website: http://faculty.virginia.edu/georgebloom/public_html.gsb4g/mainpage1.htm

Research Interests

Alzheimer's Disease

Research Description

Research in our laboratory is now focused primarily on Alzheimer's disease (AD), the most common form of a group of neurodegenerative disorders known collectively as tauopathies. The histopathological hallmark of AD is the presence in brain of extracellular plaques of β-amyloid peptide fibrils, and intraneuronal neurofibrillary tangles, which are filaments composed of the protein, tau, and are found in all tauopathies. Despite the conspicuous appearance of plaques and tangles, a growing body of evidence points to their building blocks, β-amyloid and tau oligomers, as being the toxic molecular species that cause AD. For example, we have found that tau expression is required for several adverse effects of β-amyloid oligomers on neurons, including microtubules loss, ectopic re-rentry into the cell cycle and cytotoxicity. The goals of our work are to decipher the metabolic links that connect β-amyloid and tau to damage neurons, to define the structures and pathological properties of various types of β-amyloid and tau oligomers, and to develop effective therapeutic and diagnostic tools for AD.

Selected Publications