T Lymphocyte Responses To Virus Infection
NK Cells and Viral Immunity, Genetics of host resistance to viral infection, Immunogenetics, Immune regulation
Biophysical Chemistry: Membrane protein structure, function, and dynamics
Cellular and molecular mechanisms of Neisserial pathogenesis
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.
Structural biology of membrane proteins; Structure/function and structure/stability relationships and the development of new tools for protein crystallization.
Molecular Mechanics of Muscle Contraction and Cell Movement
Immune regulation for HCV infection and chronic liver inflammation
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Structure and Function of Bacterial Toxins: Roles in Microbial Pathogenesis and Uses in Biomedical Research
Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Mechanisms used by Bacterial Pathogens to Integrate Host- and Bacterial-derived Signals to Sense their Environment, Coordinate Gene Expression, and Cause Disease
Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways
Pathogenicity of Francisella tularensis and vaccines
Regulation of lung inflammation and antimicrobial immunity
Structure-Function of Active Transporters
Molecular mechanisms of pathogenesis of parasitic infection
Human Immunodeficiency; Virus Gene Expression
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
We study papillomavirus oncoproteins as probes to elucidate cellular pathways regulating cellular signal transduction, and the development of cancer. Projects: Oncoprotein E6 and the regulation of integrin signaling and Cdc48.
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.