Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Structural and Functional Basis for Oncogenesis; Targeted Drug Development; Structural Studies of Membrane Proteins
Electrical signals in inflammation and immunity
Structural biology of membrane proteins; Structure/function and structure/stability relationships and the development of new tools for protein crystallization.
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Neural control of blood pressure and respiration
Molecular mechanisms controlling insulin signaling and fat synthesis.
Spermatogenesis and oogenesis; fertilization; cancer-testis and cancer-oocyte neoantigens.
Intercellular communication as it relates to blood pressure regulation
Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism, atherosclerosis, Small molecule approaches to drug discovery
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Neural Circuits in Healthy and Diseased Brains