Angiogenesis; peripheral arterial disease (PAD); gene therapy
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
T Lymphocyte Responses To Virus Infection
Tumor microenvironment and mechanisms of tumor neovascularization
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance
Cardiovascular Magnetic Resonance Imaging; Coronary Heart Disease; Myocardial Function; Myocardial Perfusion
Structural biology of membrane proteins; Structure/function and structure/stability relationships and the development of new tools for protein crystallization.
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Ontogeny of renin-angiotensis system, differentiation of the JG cell.
Molecular Mechanics of Muscle Contraction and Cell Movement
Neural control of blood pressure and respiration
Molecular mechanisms controlling insulin signaling and fat synthesis.
Intracellular Mechanics and Cell Function
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
Diagnostic ultrasound - image processing, quantification Molecular imaging using ultrasound Catheter-based ultrasound Ultrasound-based drug/gene delivery Ultrasound image guided therapy
Translating our discoveries in the microcirculation to tangible benefits in patients.
Systems-biology approaches to cancer biology and virology.
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.
Neuronal Vulnerability: A Study of Cellular Mechanism
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Atherosclerosis, Obesity, Diabetes
Magnetic Resonance Imaging
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis
Apoptotic cell clearance mechanisms in health and disease
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism, atherosclerosis, Small molecule approaches to drug discovery
Endocrine hypertension, angiotensin receptors, renal paracrine hormones
Cardiac Gap Junction Membrane Channels / Integrins Water Channels / Rotavirus / Reovirus / Retrovirus