Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Studies of various aspects of epilepsy using anatomy and in vivo and in vitro physiology.
Structural biology of membrane proteins; Structure/function and structure/stability relationships and the development of new tools for protein crystallization.
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Ontogeny of renin-angiotensis system, differentiation of the JG cell.
Molecular Mechanics of Muscle Contraction and Cell Movement
Neural control of blood pressure and respiration
Molecular mechanisms controlling insulin signaling and fat synthesis.
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
Translating our discoveries in the microcirculation to tangible benefits in patients.
Insulin signaling, insulin-regulated membrane trafficking and associated changes in cellular function and whole body physiology
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
Cardiac magnetic resonance imaging, myocardial disease, atherosclerotic plaque imaging, peripheral arterial disease, hypertrophic cardiomyopathy
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Behavioral and Physiological Analysis of Vertebrate Circadian Rhythms
Structure-Function of Active Transporters
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis
Endocrine hypertension, angiotensin receptors, renal paracrine hormones
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
Cardiac Gap Junction Membrane Channels / Integrins Water Channels / Rotavirus / Reovirus / Retrovirus