Basic and translational brain tumor research
Identify and target key genomic and epigenomic drivers in cancer
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Molecular Mechanisms of Transcriptional Regulation
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Regulation of gene expression during lymphocyte development
Studies of various aspects of epilepsy using anatomy and in vivo and in vitro physiology.
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Signaling Pathways and Breast Cancer
T Lymphocyte Responses To Virus Infection
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Pathways to enhance T cell function in tumors.
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer; Structural Studies of Membrane Proteins
Molecular Mechanisms for Membrane Transport and Cell Signaling
Mouse Visual System, physiology, functional imaging, genetics, molecular, behavioral, and computational methods
Hormonal control of blood pressure and kidney function; renin-angiotensin-aldosterone system; dopominergic system; renal and vascular paracrine systems; cell and molecular biology of vascular hormones.
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Herpes Simplex Virus Infection of Neurons
Biophysical Chemistry: Membrane protein structure, function, and dynamics
Cellular and molecular mechanisms of Neisserial pathogenesis
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Host/pathogen Interaction - Chlamydia Infection
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Cell Adhesion and Adhesion-Dependent Cell Signaling in Vertebrate Morphogenesis
Tumor microenvironment and mechanisms of tumor neovascularization
Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer
Structure and Function of Macromolecular Complexes Using Electron Microscopy
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity
Cardiovascular Magnetic Resonance Imaging; Coronary Heart Disease; Myocardial Function; Myocardial Perfusion
Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Signal transduction in cancer cells
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer
Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
Signal Processing by the Central Nervous System
Immune regulation for HCV infection and chronic liver inflammation
Immune response to infectious disease in the CNS
Molecular mechanisms controlling insulin signaling and fat synthesis.
Morphogenesis of the Developing Wolffian/Epididymal duct
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
Diagnostic ultrasound - image processing, quantification Molecular imaging using ultrasound Catheter-based ultrasound Ultrasound-based drug/gene delivery Ultrasound image guided therapy
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Translating our discoveries in the microcirculation to tangible benefits in patients.
Systems-biology approaches to cancer biology and virology.
Pathophysiology of Status Epilepticus; Mechanisms and pathways of seizure spread
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
Targeted delivery of therapeutic and diagnostic imaging agents.
Cardiac magnetic resonance imaging, myocardial disease, atherosclerotic plaque imaging, peripheral arterial disease, hypertrophic cardiomyopathy
The role of glia in the development, maintenance and regeneration of the nervous system
Positron Emission Tomography Imaging of Remodeling of Myocardial Glucose Metabolism in Pressure Overload Left Ventricular Hypertrophy
Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.
Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
Neuronal Vulnerability: A Study of Cellular Mechanism
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Developmental regulation of planar cell polarity in the mammalian nervous system
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Chemical biology of sphingosine 1-phosphate
Molecular Mechanisms of Myotonic Muscular Dystrophy
Transcriptional Regulation by NFKB
Atherosclerosis, Obesity, Diabetes
Magnetic Resonance Imaging
Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific Reproducibility
Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.
Structure and Function of the GI Tract in the Context of Childhood Nutrition, Growth, Immunity, and Host-microbe Interactions
Molecular pathogenesis and genomic analysis of human cancers
Magnetic Resonance Imaging Rapid and 3 D Techniques; Hyperpolarized Gases
Structure-Function of Active Transporters
Obesity and Aging
Immune mechanisms of acute kidney injury and fibrosis. Pulsed ultrasound in acute kidney injury
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates
Mechanisms of organ development and homeostasis and tumor development
Nuclear Transport, Signaling, and Cancer
Protein Evolution; Computational Biology
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Immune mechanisms of defense against enteric (diarrheal) infections
Structure and assembly of HIV Virus/host interactions; Structural biology of the innate immune system
Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis
Novel therapeutic approaches to brain cancers and to other neurologic diseases
Apoptotic cell clearance mechanisms in health and disease
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Objective and quantitative modeling of data from imaging and other types of sensors
Cardiovascular MRI, Cardiovascular CT, Echocardiography, Nuclear Cardiology, Diastolic Heart Failure, Myocardial Perfusion, Coronary Artery Disease
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Investigation of the neuronal circuits and epigenetic modifications involved in the control of food intake, impulsivity and novelty seeking behavior
Cellular and genetic determinants of atherosclerosis and restenosis.
Regulation of neural stem cell proliferation during development and adulthood
Endocrine hypertension, angiotensin receptors, renal paracrine hormones
Transcriptional Silencing and Aging in Yeast
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine
How Viruses, Particularly Papillomaviruses, Can Cause Cancer
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Genome instability in cancer and repeat expansion diseases
Structure/function of integral membrane proteins; structural biophysics; enzymology and virology of ZMPSTE24; sparse-constraint structure determination; technology development
Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.
Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.
Cellular and molecular mechanisms of allergic disease in humans.
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
Mechanisms of Huntington's Disease Pathogenesis
Neural Circuits in Healthy and Diseased Brains
Early detection, cancer prevention, and tumor microenvironment
Neuroscience and Anesthetic Neuroprotection