The Ubiquitin System and Human Cancer
Basic and translational brain tumor research
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Molecular Mechanisms of Transcriptional Regulation
Matrix Biology and Engineering
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Epigenetic and genetic mechanisms underlying metabolic disease
T Lymphocyte Responses To Virus Infection
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Pathways to enhance T cell function in tumors.
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer
Molecular Mechanisms for Membrane Transport and Cell Signaling
Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment
Mouse Visual System, physiology, functional imaging, genetics, molecular, behavioral, and computational methods
Systems Genetics Approaches to Understand Cardiometabolic Traits
Herpes Simplex Virus Infection of Neurons
Biophysical Chemistry: Membrane protein structure, function, and dynamics
Epigenetic mechanisms involved in complex human disease
Cellular and molecular mechanisms of Neisserial pathogenesis
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Host/pathogen Interaction - Chlamydia Infection
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Cell Adhesion and Adhesion-Dependent Cell Signaling in Vertebrate Morphogenesis
Tumor microenvironment and mechanisms of tumor neovascularization
Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer; Bioinformatics of cancer outcome
Structure and Function of Macromolecular Complexes Using Electron Microscopy
Macrophage effector functions in inflammation and immunotherapy
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity
Cardiovascular Magnetic Resonance Imaging; Coronary Heart Disease; Myocardial Function; Myocardial Perfusion
Immune mechanisms of pathogenic antibody production in allergy and autoimmunity
Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics
Systems Genetics of Skeletal Development and Maintenance
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Signal transduction in cancer cells
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
Circadian entrainment for the treatment of metabolic and neurodegenerative diseases
Immune regulation for HCV infection and chronic liver inflammation
Immune response to infectious disease in the CNS
Molecular mechanisms controlling insulin signaling and fat synthesis.
Morphogenesis of the Developing Wolffian/Epididymal duct
Understanding Cellular and Molecular Mechanisms Leading to Blood Vessel Formation
Diagnostic ultrasound - image processing, quantification Molecular imaging using ultrasound Catheter-based ultrasound Ultrasound-based drug/gene delivery Ultrasound image guided therapy
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Translating our discoveries in the microcirculation to tangible benefits in patients.
Systems-biology approaches to cancer biology and virology.
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
Pathophysiology of Status Epilepticus; Mechanisms and pathways of seizure spread
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Targeted delivery of therapeutic and diagnostic imaging agents.
Cardiac magnetic resonance imaging, myocardial disease, atherosclerotic plaque imaging, peripheral arterial disease, hypertrophic cardiomyopathy
The role of glia in the development, maintenance and regeneration of the nervous system
Positron Emission Tomography Imaging of Remodeling of Myocardial Glucose Metabolism in Pressure Overload Left Ventricular Hypertrophy
Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.
Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
Neuronal Vulnerability: A Study of Cellular Mechanism
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Maintaining and Breaking Immune Tolerance
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Developmental regulation of planar cell polarity in the mammalian nervous system
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Chemical biology of sphingosine 1-phosphate
Behavioral Pharmacology, Sex Differences, Animal Models of Addiction
Molecular Mechanisms of Myotonic Muscular Dystrophy
Transcriptional Regulation by NFKB
Atherosclerosis, Obesity, Diabetes
Magnetic Resonance Imaging
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific Reproducibility
Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.
Structure and Function of the GI Tract in the Context of Childhood Nutrition, Growth, Immunity, and Host-microbe Interactions
Magnetic Resonance Imaging Rapid and 3 D Techniques; Hyperpolarized Gases
Regulation and function of tyrosine phosphorylation in complex networks
Structure-Function of Active Transporters
Obesity and Aging
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates
Mechanisms of organ development and homeostasis and tumor development
Nuclear Transport, Signaling, and Cancer
Modulation of sodium channel gating by beta subunits and novel sodium channel blockers; Synaptic transmission in dorsal horn neurons
Protein Evolution; Computational Biology
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Immune mechanisms of defense against COVID-19 and enteric (diarrheal) infections
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis
Novel therapeutic approaches to brain cancers and to other neurologic diseases
Apoptotic cell clearance mechanisms in health and disease
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Objective and quantitative modeling of data from imaging and other types of sensors
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
Cardiovascular MRI, Cardiovascular CT, Echocardiography, Nuclear Cardiology, Diastolic Heart Failure, Myocardial Perfusion, Coronary Artery Disease
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Investigation of the neuronal circuits and epigenetic modifications involved in the control of food intake, impulsivity and novelty seeking behavior
Molecular and genetic determinants of atherosclerosis and cardiometabolic disorders.
Regulation of neural stem cell proliferation during development and adulthood
Tailored fit targeting approaches: Cancer Immunotherapy, Antibodies and conjugates
Endocrine hypertension, angiotensin receptors, renal paracrine hormones
Transcriptional Silencing and Aging in Yeast
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine
How Viruses, Particularly Papillomaviruses, Can Cause Cancer
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Genome instability in cancer and repeat expansion diseases
Structure/function of integral membrane proteins; structural biophysics; enzymology and virology of ZMPSTE24; sparse-constraint structure determination; technology development
Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.
Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.
The immune response to common cold and allergens in health and disease.
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
Mechanisms of Huntington's Disease Pathogenesis
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease
Early detection, cancer prevention, and tumor microenvironment
Neuroscience and Anesthetic Neuroprotection