Winckler, Bettina

Bettina Winckler

Bettina Winckler

Primary Appointment

Professor, Cell Biology

Education

  • BA, Biology, Swarthmore College
  • PhD, Biology, Massachusetts Institute of Technology
  • Postdoc, Cellular Neurobiology, Columbia University
  • Postdoc, Cellular Neurobiology, Yale University

Contact Information

Jordan Hall Rm 3073B
Telephone: 924-5528
Email: bwinckler@virginia.edu
Website: http://www.healthsystem.virginia.edu/internet/neurosci/Faculty/Winckler/Home.cfm

Research Interests

Endosomal function and dysfunction in neurons

Research Description

Many diseases of the nervous system (neurodevelopmental and neurodegenerative) as well as degenerative and regenerative processes after injury can be traced at the cellular level to disruptions of endolysosomal pathways, including autophagy. For example, Alzheimer?s disease, Huntington?s disease, and nerve injury all show profound defects in endosomal trafficking. This is not surprising given the central role of the endolysosomal system in regulating not only ?cellular trash removal,? but also the quantity and quality of signaling cascades. The Winckler lab has unique expertise in studying endolysosomal trafficking in neurons and has shown that endosomes in neurons use different molecular machineries from non-polarized cells (Yap et al., 2008; Yap et al. 2010, Lasiecka et al. 2010; Yap et al. 2012; Lasiecka et al., 2014). We are particularly interested in the roles neuronal-specific proteins, (for example the neuronal-enriched endosomal protein NEEP21) play in neuronal endosomes. We are making extensive use of live imaging to understand the function and regulation of neuronal endosomes.

Selected Publications